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Reinholz, M., et al. Multi-Site Reproducibility and Analytic Accuracy of the HTG EdgeSeq Immuno-Oncology Assay. Poster session presented at: The Association for Molecular Pathology (AMP) Global, 2017 Apr; Berlin, Germany Download

Antwerp University, et al. Next-Generation Sequencing (NGS) of Two Independent Cohorts Identifies Eleven Circulating mirNAs for Diagnosis of Nash and Fibrosis. Poster session presented at: The International Liver Congress (ILC), 2017 Apr; Amsterdam  Download

Howard K., et al. A Cross Comparison of Technologies for the Detection of Immune System Related Gene Expression Signatures in Clinical FFPE Samples of Metastatic Prostate Cancer Patients.  Poster session presented at: The American Association for Cancer Research; 2017 Apr; Washington, DC. Download

Hirsch F., et al. Heterogeneity in immune biomarker expression: Detailed analysis of a case with SCLC transformation after EGFR-TKI treatment: J Thor Oncol. 2017 Apr; in press. 
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Qi Z., et al. Reliable Gene Expression Profiling From Smaller and H&E-Stained Clinical FFPE Specimens Using HTG EdgeSeq Platform. Poster session presented at: The American Association for Cancer Research, 2017 Apr; Washington, DC Download

Balko J., et al. Advanced molecular characterization of severe autoimmune toxicities associated with checkpoint inhibitor therapies. Poster session presented at: The American Association for Cancer Research, 2017 Apr; Washington, DC Download

Danilin S. et al., Validation of our HTG EdgeSeq Platform for accurate and sensitive biomarker discovery. Poster session presented at Molecular Diagnostics Europe, 2017 Apr; 2017 Apr, Lisbon, Portugal Download

Davis B. et al. Validation of a Multiplexed Gene Signature Assay for Diagnosis of Canine Cancers from Formalin-Fixed Paraffin-Embedded Tissues. J Vet Intern Med 2017 Mar 29; doi: 10.111/jvim. 14686 [Epub ahead of print]

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Harpole D., et al. Creation and Early Validation of Prognostic miRNA Signatures for Squamous Cell Lung Carcinoma by the SPECS Lung Consortium. J Thorac Oncol. 2017 Jan; 12(1): S612-S613.




Margolles-Clark E., Ruiz P. P048 Gene Expression Profiling of Transplant Formalin-Fixed Paraffin-Embedded Biopsies: Comparison of A Custom Taqman® Low Density Array and Quantitative Nuclease-Protection Assay. Human Immunology. 2016 Sept;77(Supplement):74.  Download

Lizarraga D., et al. miRNAs differentially expressed by next-generation sequencing in cord blood buffy coat samples of boys and girls. Epigenomics. 2016 Dec; 8(12):1619-1635.

Lo B., et al. Combining Automated Tissue Dissection with Extraction Free Nucleic Acid Analysis. J Mol Diag. 2016, 18: 1048.  Download

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LeCluyse E., et al. A multiplex approach to investigate drug-induced changes in p450 enzyme gene expression. Drug Metab Rev. 2016 Jul; 48(Suppl 1):22.   Download (PDF 616KB)

Lipchik C, et al. FFPE Tissue and the HTG Oncology Biomarker Panel: a Low-Input, Extraction-Free Gene Expression Pilot Study. Poster presented at:  The Mid-Atlantic Directors and Staff of Scientific Cores; 2016; Pittsburgh, PA.  Download (PDF 2.93MB)   

Reinholz M, et al. Next-Generation Sequencing from DLBCL Classification. J Clin Oncol. 2016;34(Suppl):abstr 11559. Download (PDF 740KB)

Sunakawa, Y., et al. Association of gene signature to identify molecular subtypes with clinical outcomes of 1st-line cetuximab (cet) treatment for metastatic colorectal cancer (mCRC). J Clin Oncol. 2016;34(Suppl):abstr 3592. 

Sunakawa, Y., et al. Immune-related genes to predict clinical outcome of cetuximab (cet) treatment for metastatic colorectal cancer (mCRC): Immuno-Oncology assay research. J Clin Oncol. 2016;34(Suppl):abstr. 11591.

Reinholz M., et al. Verification of miRNA Expression Using Nuclease Protection and Targeted Next-Generation Sequencing. Poster session presented at The European Society of Human Genetics; 2016; Barcelona, Spain. Download (PDF 2.07MB)

Wang, S., et al. Hsa-miR-24-3p increases nasopharyngeal carcinoma radiosensitivity by targeting both the 3′UTR and 5′UTR of Jab1/CSN5. Oncogene. 2016 Nov 24; 35(47):6096–6108. Download (PDF 2.3MB)

Hollander Z., et al. Biomarkers Monitoring for Absence of Acute Allograft Rejection. J Heart Lung Transplant. 2016 Apr; 35(4):S33.

Reinholz M., et al. Gene Expression Measurement of Immuno-Oncology Targets in a Single FFPE Section Using a Novel Targeted Sequencing Assay. Cancer Res. July 15 2016;76(14 Suppl):abstr 2237. Download (PDF 1.52MB)

Reinholz M., et al. NGS-based measurement of gene expression of 2560 oncology-related biomarkers in formalin-fixed, paraffin-embedded (FFPE) tissues. Cancer Res. 2016;76(14 Suppl):abstr 1383. 

Reinholz M., et al. The HTG EdgeSeq Oncology Biomarker Panel enables NGS-based gene expression profiling from small samples Poster session presented  at:  Association of Biomedical Research Cores; 2006 Feb  20-23;Fort  Lauderdale, FL  Download (PDF 1.13MB) 

Botros I., et al. Unique Endogenous Controls for Extraction-Free Targeted RNA Sequencing Assays. Poster session presented at: Advances in Genome Biology and Technology; 2016 Feb 10-13;Orlando, FL. Download (PDF 2.2MB)

Semrad, T., et al. Phase II study of dovitinib in patients progressing on anti-vascular endothelial growth factor therapy. J Clin Oncol. 2016:34(Suppl 4S):A616. Download (PDF 847KB)

Sunakawa, Y., et al. Alteration of ADCC-related genes as a novel predictor of efficacy of cetuximab (cet)-based chemotherapy in patients (pts) with metastic colorectal cancer (mCRC). J Clin Oncol. 2016 Jul;34(Suppl 4S):A589. Download (PDF 463KB)



Barczak A.J., et al.  Reproducibility and Bias of miRNA Profiling with the HTG EdgeSeq Targeted Capture and Sequencing Assay. Poster session presented at: The External RNA Control Consortium (ERCC) 2015 meeting.

Chen L.Q., et al. Assessment of carbonic anhydrase IX expression and extracellular ph in B-cell lymphoma cell line models. Leuk Lymphoma. 2015 May; 56(5):1432–1439.

Baker, A.F., et al. Evaluation of a Hypoxia Regulated Gene Panel In Ovarian Cancer. Cancer Microenviron. 2015 Apr;8(1):45-56. Baker,  Download (PDF 864K)

Reinholz M., et al. HTG EdgeSeq Oncology Biomarker Panel (OBP), an NGS-based Measurement of Gene Expression of 2,532 Oncology-Related genes in FFPE tissue in different sample types. Poster session presented at: 8th GTCBio Oncology Biomarkers Conference; 2015, San Diego, CA. Download (PDF 1.09MB)

Liang J., et al. LEF1 targeting EMT in prostate cancer invasion is mediated by miR-181a. Am J Cancer Res. 2015 Feb 15;5(3):1124-1132.

Maddula K., et al. Targeted RNA Sequencing for simultaneous expression profiling and detection of gene rearrangements in FFPE biopsies. Poster session presented at: Advances in Genome Biology and Technology; 2015; Marco Island, FL. Maddula K, et al. Download (PDF 1.15MB)

Schwartz, M, et al. Repeatability and reproducibility of an automated, multiplex p450 enzyme gene expression assay. Poster presented at 2015 ISSX; 2015 Oct 18 - 22. Download (PDF 1.2MB)



Thompson D., et al. Automated high fidelity miRNA expression profiling using nuclease protection coupled with next generation sequencing. Poster session presented at: 64th annual meeting of the American Society of Human Genetics; 2014 October 18-22; San Diego, CA

Barr P.M., et al. Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma. Blood. Aug 2014 Vol 124:8.

Ren Q., et al. Epithelial and stromal expression of miRNAs during prostate cancer progression. Am J Transl Res. 2014 Jul 18;6(4):329-39.

Thompson D., et al. Automated high fidelity miRNA expression profiling using nuclease protection coupled with next generation sequencing. Poster session presented at: Merck Technology Symposium; 2014 May; Long Branch, NJ. Download (PDF 1.49MB)

Maddula K., et al. FGFR and FGF ligand overexpression in lung cancer: Implications for targeted therapy. J Clin Oncol. 2014;32(Suppl 5):abstr 11080. Download (PDF2.1MB) 

Shell S., et al. Correlation of multiplex measurement of mRNA expression from FFPE tissues with protein expression. J Clin Oncol. 32, 2014;32(Suppl):abstr e22141.FFPE tissues with protein expression. J Clin Oncol. 32, 2014;32(Suppl):abstr e22141.

Maddula K., et al. RNA expression based screening of ALK Gene Fusion from NSCLC FFPE samples. Cancer Res. 2014;74(19 Suppl):abstr 1904.

Wang E., et al. Non-small cell lung cancer histological sub-typing by gene expression analysis from FFPE tissue. Cancer Res. 2014;74(19 Suppl):abstr 1877.

Hollander Z., et al. Blood test to Monitor for the Absence of Acute Cardiac Rejection: From Discovery to Clinical Implementation. J Heart Lung Transplant. 2014 Apr; 32(Suppl 4).

McPherson C., et al. In Vivo Molecular Markers for Pro-inflammatory Cytokine M1 Stage and Resident Microglia in Trimethyltin-Induced Hippocampal Injury. Neurotox Res. 2014 Jan 25(1):45-56.

Whitman S, et al. A multiplex approach to investigate drug-induced changes in p450 enzyme gene expression.Poster presented at 2014 ISSX; 2014 Oct 19 - 23. Download (PDF 2.5MB)



Liu Z., et al. miR-106a Represses the Rb Tumor Suppressor p 130 to Regulate Cellular Proliferation and Differentiation in High-Grade Serous Ovarian Carcinoma. Mol Cancer Res. 2013 Nov 1;11(11):1314-1325.

Rounseville M., et al. Development of an automated RNA-based nuclease protection assay for the detection of expressed EML-ALK fusions, EGFR and KRAS mutations in NSCLC. J Clin Oncol. 2013;31(Suppl); abstr e22185.

Seligmann B., et al. miRNA Biomarker Identification Using a Sequencing-Based Nuclease Protection Assay (NPSeq™). J Biomol Tech. 2013 May;24(Suppl). Download (PDF 694KB)

Thompson D., et al. Targeted gene expression sequencing from FFPE: NPSeq™. Cancer Res. 2013;73(8 Suppl):abstr 4146. Download 

Rounseville M., et al. Comparison of qNPA vs qPCR on FFPE tissue. Cancer Res. 2013;73(8 Suppl):abstr 4133. Download (PDF 733KB)

Yang D., et al. Array-based Quantitative Nuclease Protection Assay Can Reproducibly Identify Prognostic mRNA Biomarkers in Archival Mantle Cell Lymphoma Specimens. Mod Pathol. 2013 Feb;26(S2):368A. Download (PDF 1.1MB)

Seligmann B., et al. miRNA Biomarker Identification Using a Sequencing-Based Nuclease Protection Assay (NPSeq): Building on Edge Automation of qNPA for RNA Measurement. J Biomol Tech. 2013 May;24(Suppl):S34-S35.

Chandler K., et al. Investigation of a Redox-Sensitive Predictive Model of Mouse Embryonic Stem Cell Differentiation via Quantitative Nuclease Protection Assays and Gluthione Redox Status. Poster session presented at: 52nd Annual Society of Toxicology Meeting; 2013 Mar 10-14, San Antonio, TX.

Rounseville M., et al. Automated Measurement of Gene Expression from FFPE: qNPA vs. qPCR. Poster session presented at: Molecular Med Tri-Con; 2013 Feb 11-15; San Francisco, CA   Download (PDF 849KB)

Barr P.M., et al. Redox Associated Gene Expression Predicts for Responses to The Pro-Oxidant Molecule Imexon in Relapsed and Refractory B-Cell Non-Hodgkin Lymphoma: Results of a Multi-Center Phase II Study. Blood. 2013;122(21):89.

Modur  V, et al. Evidence-based laboratory medicine in oncology drug development: From biomarker to diagnostics. Clin Chem. 2013 Jan;59(1):102-9.

Hunter E, et al. Investigation of a Redox-Sensitive Predictive Model of Mouse Embryonic Stem Cell Differentiation via Quantitative Nuclease Protection Assays and Glutathione Redox Status. Poster presented at the 52nd Annual Society of Toxicology Meeting; 2013 Mar 10-14 (abstr 1205).

Brengues M, et al. Biodosimetry on Small Blood Volume using Gene Expression Assay. Health Phys. Author manuscript; PMC 2013 June 10.



Erickson H.S. Measuring molecular biomarkers in epidemiologic studies: laboratory techniques and biospecimen considerations. Stat Med. 2012 Sep 28;31(22):2400-13.

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Guerau-de-Arellano M., et al. miRNA profiling for biomarker discover in multiple sclerosis: From microarray to deep sequencing. J Neuroimmunol. 2012 Jul 15; 248(1-2):32-39.

Bakir F., et al. Discovery and Structure-Activity Relationship Studies of Indole Derivatives as Liver X Receptor (LXR) Agonists. Bioorg Med Chem Lett. 2007 Jun 15;17(12): 3473–3479.



Evangelist M., et al. Quantitative Nuclease Protection Assay (qNPA) for Gene Expression Analysis on Brest Cancer Core Biopsies. J Clin Oncol. 2011 Sep 20;29(Suppl 27);abstr 49.

Bourzac K., et al. A High-Density Quantitative Nuclease Protection Microarray Platform For High Throughput Analysis of Gene Expression. J Biotechnol. 2011 Jun 10;154(1):68-75.

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Yang D., et al. Identification of Potential Prognostic Biomarkers in Mantle Cell Lymphoma by Array-Based Quantitative Nuclease Protection Assay. Blood. 2010 Nov 19;116: abstr 2007.

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Altar C., et al. Insulin, IGF-1, and Muscarinic Agonists Modulate Schizophrenia-Associated Genes in Human Neuroblastoma Cells. Biol Psychiatry. 2008 Dec 15;64(12);1077-1087.

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