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USCAP 2020 Customer Poster by Dr. Michael J. Hwang

Sarcomatoid Renal Cell Carcinoma Demonstrates an Immunosuppressive Tumor Microenvironment – Implication for Therapeutic Benefit in the Immunotherapy Era

Renal cell carcinoma (RCC) with sarcomatoid features (sRCC) is an aggressive form of RCC with poor response to conventional therapies. Immune checkpoint inhibitors have shown promising therapeutic effect for sRCC in recent small series and sRCC has demonstrated higher PD-L1 expression and PD-1 positive tumor-infiltrating lymphocytes compared to high-grade clear cell RCC (ccRCC). Our aim was to use multiplexed gene expression assays to gain a broader view of the underlying tumor microenvironment in sRCC.

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Page last updated June 01, 2020