HTG EdgeSeq Pan B-Cell Lymphoma Panel
Measure gene expression of mRNA targets commonly associated with indolent and aggressive lymphomas to help identify lymphoma subgroups to elucidate the transcription response of disease state and drug therapy. With 298 gene targets, the HTG EdgeSeq Pan B-Cell Lymphoma Panel addresses the heterogeneity of B-Cell lymphomas, including published signatures and drug targets. Leveraging the sensitivity and dynamic range of next-generation sequencing (NGS), the HTG EdgeSeq Pan B-Cell Lymphoma Panel enables multiplex profiling from limited formalin-fixed, paraffin-embedded (FFPE) samples. The ability to work with small tissues is critical when considering that 10-15% of specimens in clinical practice do not qualify due to high sample requirements (PMID: 30248164). This extraction-free HTG EdgeSeq assay is automated on the HTG EdgeSeq system or available at our VERI/O lab as a service.
For Research Use Only. Not for Use in Diagnostic Procedures.
Features and Benefits
- Measure 298 transcripts in a single well:
obtain a broad profile of genes associated with B-cell lymphomas from a single analysis - Extraction-free chemistry:
proprietary sample preparation workflow that reduces bias and sample loss associated with extracted RNA - Low sample input:
reliable results with as little as 6.0 mm2 tissue area per sample well - Simplified data analysis:
determine the Cell of Origin predicted probability of GCB for diffuse large B-cell lymphomas using the fully integrated
HTG EdgeSeq Reveal data analysis pipeline
Sample Requirements and Options
| Sample Type | Recommended Sample Input |
|---|---|
Larger sample input amounts must be diluted. Please consult the assay package insert and HTG EdgeSeq System User Manual for more details. |
|
| FFPE Tissue | One 5 µm section |
Lymphoma Subtypes
The Following Lymphoma Subtypes are targeted by the HTG EdgeSeq Pan B-Cell Lymphoma Panel:
| Diffuse large B-cell lymphoma |
| Plasmablastic lymphoma |
| Mantle cell lymphoma |
| Chronic lymphocytic leukemia |
| Marginal zone lymphoma |
| Burkitt lymphoma |
| Primary mediastinal B-cell lymphoma |
| Lymphoplasmacytic lymphoma |
| Double hit lymphoma |
| Molecular high-grade lymphoma |
| Folicular lymphoma |
| Myeloma |
Ordering Information
When placing an order, please specify the catalog number. The HTG EdgeSeq Pan B-Cell Lymphoma Panel is compatible with the Illumina sequencers in the U.S. and E.U.
Kit Configurations for use with Illumina Sequencers (US)
916-017-208 HTG EdgeSeq Pan B-Cell Lymphoma Panel (2x8)
916-017-008 HTG EdgeSeq Pan B-Cell Lymphoma Panel (4x8)
916-017-224 HTG EdgeSeq Pan B-Cell Lymphoma Panel (1x24)
916-017-024 HTG EdgeSeq Pan B-Cell Lymphoma Panel (4x24)
916-017-096 HTG EdgeSeq Pan B-Cell Lymphoma Panel (1x96)
Kit Configurations for use with Thermo Fisher Scientific Ion Torrent Sequencers
916-017-308 HTG EdgeSeq Pan B-Cell Lymphoma Panel (2X8)
916-017-108 HTG EdgeSeq Pan B-Cell Lymphoma Panel (4X8)
916-017-324 HTG EdgeSeq Pan B-Cell Lymphoma Panel (1X24)
916-017-124 HTG EdgeSeq Pan B-Cell Lymphoma Panel (4X24)
916-017-196 HTG EdgeSeq Pan B-Cell Lymphoma Panel (1X96)
For Research Use Only. Not for Use in Diagnostic Procedures.
Resources and Publications
Learn more about the HTG EdgeSeq Pan B-Cell Lymphoma Panel
HTG EdgeSeq Pan B-Cell Lymphoma Panel Product Sheet
Download pdf 131KB
Publications
Case Study Workshop: Diffuse Large B-Cell Lymphoma Of The Testis And Cns With Aberrant Co-Expression Of Cd10, Bcl6 And Mum1/Irf4, Abc-Gep, Mcd/C5 Genetic Subtype And Irf4 Alteration
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Genetic and Molecular Subtyping of DLBCL With Very Early Treatment Failure
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Classification Of Aggressive B-Cell Lymphomas Using Gene Expression Profiling
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Analysis of the microenvironment of follicular lymphoma by gene expression analysis: importance of the Th17 axis
Download pdf 2.2MB
View External Link
Learn More
For further information about the HTG EdgeSeq Pan B-Cell Lymphoma Panel, please fill out the registration form below or call us at (877) 507-3259.
Page last updated June 29, 2022