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Molecular Profiling and More for Your Samples

VERI/O Laboratory Services supports retrospective molecular profiling studies for biopharma clients and  translational medicine researches. In addition to sample processing services using HTG’s on-market products, we also offer early access to our newest technologies, such as our direct sequencing chemistry that run exclusively in the VERI/O lab.  

To support our molecular profiling offerings, the ISO:13485 certified and GLP compliant VERI/O laboratory also provides assay development, sample accessioning, and data analysis services to support studies. 

Let VERI/O Laboratory Services be an extension of your organization.  Take advantage of the benefits of our
HTG EdgeSeq technology without the up-front capital expense.

VERI/O Laboratory Services:

  • Retrospective sample processing
  • Pilot studies
  • Custom assay development
  • Disease-specific validation studies

For custom assays, please contact HTG directly.

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Service Offerings

VERI/O Laboratory Services accepts a wide variety of clinical samples for testing, including formalin-fixed, paraffin-embedded (FFPE) tissue, plasma/serum, PAXgene, extracted RNA, and cells. Sample types and amounts are specific to each assay and customer project.

“HTG has been a true partner and collaborator in our drug development program and we truly appreciate their support to meet the regulatory filing deadline for one of our key drug products.”
~ Senior Manager, Clinical Biomarkers—Oncology, Global Pharma Partner

How VERI/O Laboratory Services Fit in the Drug Development Process

Preclinical & RetrospectiveProspective Patient EnrollmentCompanion Diagnostics (CDx)
   

RUO

IUO

IVD

Analytical validationLabeled & distributed under approved clinical protocolGlobal commercialization
Global regulatory approvals
Clinical validation
VERI/O Laboratory Services or your labQualified Service Provider (QSP) or Contract Research Organization (CRO)Laboratories worldwide

Benefits

  • Molecular profiling expertise - highly trained and dedicated staff delivering high-quality data leveraging the advantages of the HTG EdgeSeq technology.
  • Focused on turnaround times - receive a customized report on tens to thousands of biomarkers to meet your timelines.
  • Deferred investment cost - all the advantages of targeted next-generation sequencing (NGS)-based results without the capital investments, training, and labor costs.

Products/Services Comparison

There are several ways to take advantage of the unique benefits of the HTG EdgeSeq technology. 

 

 VERI/O Laboratory ServicesIn Your Lab Using The HTG EdgeSeq SystemHTG Qualified Service Providers
 * Only available in RUO mode.
** CE-IVD, EU only.
   
HTG EdgeSeq Custom AssayYesYesYes
HTG EdgeSeq ALKPlus Assay EUYes*Yes**Yes
HTG EdgeSeq DLBCL Cell of Origin Assay EUNoYes**Yes
HTG EdgeSeq DLBCL Cell of Origin AssayYesYesYes
HTG EdgeSeq Immuno-Oncology AssayYesYesYes
HTG EdgeSeq miRNA Whole Transcriptome AssayYesYesYes
HTG EdgeSeq Oncology Biomarker PanelYesYesYes
HTG EdgeSeq PATH AssayYesYesYes
HTG EdgeSeq EGFR, KRAS, and BRAF Mutation AssayYesNoNo

Applications in Immuno-Oncology

ApplicationsFeaturesBenefits
Tumor microenvironment

Measure the gene expression of microdissected tumor subsections such as vasculature, stroma, and tumor from a single FFPE tissue section

Develop insights into the tumor biology

  • Tumor-infiltrating lymphocyte (TIL) composition and density
  • Interferon gamma expression levels
  • T-cell effector status
  • Cytokine expression
  • Immunomodulation
Cytokine / chemokines

Simultaneous monitoring of multiple chemokines and cytokines within cancer tissue and associated stroma

Spatial-temporal mapping of immune-stimulatory or suppressant signals

Resistance / relapse system biology

Characterization of pathway modulators that impact cancer drug response

  • Better understanding of how disease progression is tied to underlying tumor biology
  • Investigate alternative clinically actionable drug targets for late stage cancer patients
Histology

Measure the expression of cytokeratins, clusters of differentiation, epithelial genes and other histological markers

  • Identify or confirm histological grading of critical specimens
  • Sub-classify cancers into subtypes
Signaling pathways

Assess the status of pathways such as:

  • Angiogenesis/vasculature
  • Apoptosis
  • Epithelial-mesenchymal transition
  • Stem cell markers

Grouping tumors via common dysregulated molecular pathways can provide deeper molecular understanding of tumors

Other Applications

ApplicationsFeaturesBenefits
Immune checkpoint expression within molecular subtyped diffuse large B-cell (DLBCL) tumors

Characterization of immunocheckpoint factors together with tumor infiltrating lymphocyte (TIL) markers within DLBCL tumors classified via subtype

Investigate tumor immune-responsiveness of DLBCL tumors

miRNA profiling of tumors and liquid biopsies

Identify tumor miRNA-based signatures from different sample types using whole transcriptome miRNA profiling

Identify tissue-based miRNA profiles that can be translated to blood samples

Immunophenotyping immune cells

Pseudo-flow analysis using cluster of differentiation (CD)-based markers

Sensitivity and ability to multiplex above applications/markers

Subtyping DLBCL tumors

Characterize cases as Activated B-Cell Type (ABC) vs. Germinal Center B-Cell Type (GCB)

Stratify groups for biomarker and drug development

Sample Types and Input Requirements

Sample Type HTG EdgeSeq miRNA Whole Transriptome AssayHTG EdgeSeq Oncology Biomarker Panel, HTG EdgeSeq Immuno-Oncology AssayHTG EdgeSeq DLBCL Cell of Origin Assay

Values listed are for a single replicate. Multiply value by number of replicates if more than 1.

Plasma/SerumInput:12.5μL/well--
 Shipping Req:35μL/well--
PAXGeneInput:32μL/well32μL/well-
 Shipping Req:500μL500μL-
FFPE TissueInput:12.5mm25-12.5mm25mm2
 Shipping Req:30mm212-30mm212mm2
Extracted RNAInput:10-35 ng/well10-35 ng/well-
 Shipping Req:15μL @ 5 ng/μL5-15μL @ 5 ng/μL-
CellsInput:10,000 cells/well10,000 cells/well-
 Shipping Req:10,000 μL @ 4,000 cells/μL10,000 μL @ 4,000 cells/μL-

Learn More

For more information about VERI/O Laboratory Services, please fill out the form below. Or call us at (877) 507-3259.

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Page last updated November 06, 2017

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