The goal of most biologic research, including the pursuit of novel therapies to fight disease, is to generate ROBUST data sets so that reliable correlations can be established. But what does “robust” mean when it comes to RNA gene expression profiling (GEP)?
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Micro RNAs exert significant influence on our cells and ultimately our health. Our understanding of these short ribonucleic acids segments has continued to evolve since their discovery in the early 1990s. Recent discoveries now indicate that there are two different and major modes of miRNA regulation.
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The gold standard for gene expression profiling is bulk RNA sequencing (RNA-seq). RNA-seq performed on biologic samples reveals the specific genes which are differentially expressed under certain conditions. To complement the information obtained from bulk RNA-seq researchers have developed single-cell RNA sequencing (scRNA-seq) techniques. As the name implies, scRNA-seq focuses on obtaining the RNA profiles of a specific type of cells extracted from a heterogeneous sample. Yet another innovation in the field of gene expression came with the development of the Spatial Gene Expression Profiling (spatial GEP) technique.
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RNA sequencing, also known as RNA-seq, is a genomic method for finding and quantifying messenger and micro RNA molecules in a biological sample. Examples of scRNA-seq and multi-cell/bulk (sourced from multiple cells or bulk tissue sample) RNA profiling complementing each other can be found across numerous scientific research disciplines.
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On November 4, 2022 HTG will host another event in their webinar series featuring Dr. Pierre Saintigny, Professor of Medicine at University Claude Bernard Lyon 1 and medical oncologist at the Léon Bérard Cancer Center (CLB). Registration is free and an on-demand replay will be made available after the event for registrants who were unable to join live.
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When it comes to bulk RNA research the lack of workers has caused a backlog of research testing which is essential to advance the development of safe and effective therapies for many conditions including life-threatening cancers. HTG EdgeSeq is a sample-sparing approach to gene expression profiling and that means that precious biobanks can be preserved and less time will be spent collecting and processing crude tissue samples.
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Peripheral artery disease (also called peripheral arterial disease or PAD) is a common vascular condition in which narrowed arteries reduce blood flow to the arms or legs.
Critical limb ischemia (CLI) is a severe blockage in the arteries of the lower extremities, which markedly reduces blood-flow.
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We sat down with the CEO of HTG, John Lubniewski, to hear about the company’s history, discuss the present focus, and get a glimpse of the future plans.
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A volcano plot is useful for identifying events that differ significantly between two groups of experimental subjects. The name volcano plot comes from its resemblance to a volcanic eruption with the most significant points at the top, like spewed pieces of molten lava.
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There is a growing interest in research into different types of RNAs as they are all puzzle pieces needed to form a complete picture of epigenetics. Currently, mRNA and miRNA molecules are most commonly used for RNA based GEP.
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HTG EdgeSeqTM (EdgeSeq) technology and HTG Transcriptome Panel (HTP) produce a comprehensive and quantitative map of a cell’s transcriptomic response.
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HTG EdgeSeq Reveal is a statistical analysis package designed to evaluate and analyze parsed data files generated from assays performed using the HTG EdgeSeq system.
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Page last updated January 20, 2023