Publications

NATURE SHORTCAST: Utilizing GEP to Integrate Biomarker Data and Illuminate Complex Biology

Originally aired on: Tuesday, September 18, 2018

This presentation will highlight our newly released HTG EdgeSeq Precision Immuno-Oncology Panel that was specifically developed to answer a wide range of translational questions tied to immuno-oncology and known drug resistance pathways.

MicroRNAs in CSF as prodromal biomarkers for Huntington’s disease

Originally aired on: Tuesday, May 29, 2018

The Myers lab has studied microRNAs (miRNA) in Huntington disease (HD) brain, plasma and cerebrospinal fluid (CSF).  In a study to assess the potential of miRNAs as biomarkers for disease, we found increased miRNA levels were detected in CSF for carriers of the HD trinucleotide repeat expansion mutation up to twenty years before expected disease onset.  Levels increased as proximity to onset decreased suggesting miRNAs may serve as effective biomarkers for prodromal disease long before disease manifestation. 

Integrated Molecular Profiling of Genitourinary Tumors: Applications for Personalized Radiotherapy

Originally aired on: Wednesday, June 28, 2017

In this webcast, Dr. Omar Mian, from Cleveland Clinic Foundation,  will:

• Review the basic principles of personalized radiotherapy
• Describe the clinical unmet need for improved molecular biomarkers
• Understand the rationale for tumor profiling in terms of genotype / phenotype relationships
• Recognize the value of integrated approaches exploring genetic, structural, and epigenetic alterations
• Discuss the value of cell free DNA as a biomarker in non-invasive detection

Evaluation of a novel microRNA Whole Transcriptome Assay

Originally aired on: Wednesday, April 12, 2017

In this webcast, the performance of the HTG EdgeSeq miRNA Whole Transcriptome Assay (WTA) is evaluated using the samples and methods from the miRQC study. 

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FFPE Tissue and the HTG EdgeSeq Oncology Biomarker Panel

Originally aired on: Tuesday, September 20, 2016

HTG EdgeSeq Oncology Biomarker Panel covers 2,560 genes.  This pilot study examined different amounts of tissue input from 3 colorectal and 2 breast tumors down to 3.1 mm2, representing ¼ the recommended input.

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New tools for Biomarker Discovery Promise Personalized Treatment for Rheumatoid Arthritis

Originally aired on: Tuesday, July 26, 2016

This webinar outlined an ongoing project to develop personalized treatment strategies for rheumatoid arthritis patients using miRNA profiling. 

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Expression-Based Profiling of Challenging FFPE Tumor Samples

Originally aired on: Thursday, May 19, 2016

This webinar focused on recent advances in gene expression profiling of challenging formalin-fixed, paraffin-embedded tissue samples for cancer research and clinical practice. The presentation covered studies in non-small cell lung cancer and pancreatic cancer. 

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NGS-Based miRNA Profiling to Develop Signatures of Potential Clinical Applications

Originally aired on: Wednesday, December 2, 2015

This webinar discusses potential clinical applications for miRNA signatures and a novel, extraction-free miRNA profiling technology for advancing biomarker discovery. 

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