Applications

Future Tumor Profiling Applications

The HTG EdgeSeq miRNA Whole Transcriptome Assay (v20) and HTG EdgeSeq Biomarker Oncology Panel provide comprehensive approaches to understand the miRNA and mRNAs which are playing a role in tumor biology. Other aspects of the tumor’s biology, including gene fusion / rearrangement status, protein expression profile, and DNA mutational status have been shown to be relevant to the behavior of the tumor.

miRNA Profiling

MicroRNAs (miRNAs) are ~22nt non-coding strands of expressed RNA that are used by the cell for gene regulation. While research in this area is still young, these molecules have been implicated in various forms of disease, which makes miRNA profiling a viable method for biomarker discovery.

Profiling mRNA in FFPE with the HTG EdgeSeq Oncology Biomarker Panel

Message RNA (mRNA) conveys genetic information from DNA to the ribosome for protein synthesis.  While every cell contains an entire genome, every tissue type has a unique expression profile. Tumor tissues exhibit abnormal profiles when compared to their normal counterparts, and tumor profiling can further elucidate the characteristics of a particular cancer.

Example:

Analysis of Common Breast Oncology Biomarkers 

 

 

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