There are a numerous articles and presentations supporting the effectiveness of HTG Molecular’s qNPA technology and its ability to identify the right targets while saving time and resources in the practical laboratory setting. Please see the most recent publications supporting this research here.

Recent Publications

Bourzac KM, Rounseville MP, Zarate X, Maddula VS, Henderson DC, Luckey JA, Seligmann B, Galbraith DW. A High-Density Quantitative Nuclease Protection Microarray Platform For High Throughput Analysis Of Gene Expression. (2011) http://www.ncbi.nlm.nih.gov/pubmed/21504771

M. C. Evangelist, J. Krushkal, Y. Qu, A. Kulkarni, B. Kerns, B. Seligmann, J. C. Sachdev; University of Tennessee Health Science Center, Memphis, TN; HTG, Tucson, AZ. Quantitative Nuclease Protection Assay (qNPA) for Gene Expression Analysis on Breast Cancer Core Biopsies. (2011) ASCO http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=102&abstractID=82668

Rimsza, L., Wright, G., Schwartz, M., et al. Classification of Diffuse Large B cell Lymphoma into Germinal Center and Activated B cell Subtypes Using a Nuclease Protection Assay on Paraffin Embedded Tissues. (2011) http://clincancerres.aacrjournals.org/content/17/11/3727

Grow, M., Choudhury, B., Rounseville, M., Thompson, D., Sekinger, E. High Correlation Achieved between Mirrored Frozen and FFPE Samples Using the qBead Multiplex Gene Expression Assay. (2011) AACR

David T Yang, MD, Gene R Shaw, MD, PhD*, Kreg M Grindle, Songwon Seo, Catherine Leith, MBBChir, Ken H Young and Brad Kahl, MD. Identification of Potential Prognostic Biomarkers in Mantle Cell Lymphoma by Array-Based Quantitative Nuclease Protection Assay. (2010) ASH http://ash.confex.com/ash/2010/webprogram/Paper34246.html

Fichorova, R. N.., Trifonova, R. T., Doncel, G.F. Polyanionic Microbicides Modify Toll-Like Receptor-Mediated Cervicovaginal Immune Responses. (2009) http://aac.asm.org/cgi/content/abstract/53/4/1490

Pechhold S, Stouffer M, Walker G, Martel R, Seligmann B, Hang Y, Stein R, Harlan DM, Pechhold K. Transcriptional Analysis of Intracytoplasmically Stained, FACS-Purified Cells By High Throughput, Quantitative Nuclease Protection. (2009) http://www.nature.com/nbt/journal/v27/n11/abs/nbt.1579.html#abs

Altar, CA., Vawter, MP., Ginsberg, SD. Target Identification for CNS diseases by transcriptional profiling. (2008) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675576/?tool=pubmed

Rimsza, L., LeBlanc, M., Unger, J., et al. Gene Expression Predicts Overall Survival in Paraffin Embedded Tissues of Diffuse Large B Cell Lymphoma Treated with R-CHOP. (2008) http://bloodjournal.hematologylibrary.org/content/112/8/3425.full.pdf+html

Altar, CA., Hunt, RA., Jurata, LW., Webster, MJ., Derby, E., Gallagher, P., Lemire, A., Brockman, J., Laeng, P. Insulin, IGF-1, and Muscarinic Agonists Modulate Schizophrenia-Associated Genes in Human Neuroblastoma Cells. (2008) http://www.ncbi.nlm.nih.gov/pubmed/18973876

Bakir, F., Kher, S., Pannala, M., et al. Discovery and Structure-Activity Relationship Studies Of Indole Derivatives as Liver X Receptor (LXR) Agonists. (2007) http://www.ncbi.nlm.nih.gov/pubmed/17416521

Kris, R., Felder, S., Deyholos, M., et al. High-Throughput, High-Sensitivity Analysis of Gene Expression in Arabidopsis. (2007) http://www.plantphysiol.org/content/144/3/1256.full.pdf+html

Roberts, R., Sabalos, C., Martel, R., et al. Quantitative Nuclease Protection Assay in Paraffin-Embedded Tissue Replicates Prognostic Microarray Gene Expression in Diffuse Large B-Cell Lymphoma. (2007) http://www.nature.com/labinvest/journal/v87/n10/abs/3700665a.html

Sawada, H., Taniguchi, K., Takami, K., et al. Improved Toxicogenomic Screening for Drug-Induced Phospholipidosis Using a Multiplexed Quantitative Gene Expression ArrayPlate Assay. (2006) http://www.ncbi.nlm.nih.gov/pubmed/16919414

Martel, R., Staples, R., Hinton, J., et al. Array Formats in Microarray Technologies and Applications. (2003) http://www.springerlink.com/content/t407r557j5574556/

Martel, R., Rounseville, M., Botros, I., et al. Multiplexed Chemiluminescence Assays in ArrayPlates for High-Throughput Measurement of Gene Expression. (2002) http://spiedigitallibrary.org/proceedings/resource/2/psisdg/4626/1/35_1?isAuthorized=no

Martel, R., Rounseville, M., Botros, I., et al. Multiplexed Molecular Profiling (MMP) Transcription Assay in ArrayPlates for High-Throughput Measurement of Gene Expression. (2002) http://spiedigitallibrary.org/proceedings/resource/2/psisdg/4626/1/35_1?isAuthorized=no

Martel, R., Botros, I., Rounseville, M., et al. Multiplexed Screening Assay for mRNA Combining Nuclease Protection with Luminescent Array Detection. (2002) http://www.liebertonline.com/doi/abs/10.1089/154065802761001310